تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق

محتوى المقالة الرئيسي

Ahmed jaber ibrahim
https://orcid.org/0000-0003-4245-7618
Arwa H. M. AL–Saeed
https://orcid.org/0000-0002-6447-8965

الملخص

بيتا ثلاسيميا هي واحدة من أكثر الأمراض الوراثية شيوعًا في العالم بسبب نقص سلاسل الكلوبين. تعتبر أمراض القلب من المضاعفات الرئيسية لهذا المرض نتيجة ترسب الحديد الزائد في أنسجة القلب. أخذ 100 مريض تتراوح أعمارهم بين 2-18 عامًا تم تشخيص إصابتهم بـ ß-TM في الدراسة الحالية التي تم قبولها في مركز ذي قار لأمراض الدم الوراثية في مدينة ذي قار بالعراق ، و80 مشاركًا سليمًا ، متطابقين مع العمر والمنطقة الجغرافية تم تبنيها كمجموعة تحكم. لتقييم مصل تروبونين 1 (c.TnI) و إنزيم الكرياتين كيناز القلبي(CK-MB)  وبروتين الابلين و انزيم اسبارتيت امينوترانسفيريز ((AST وإنزيم لاكتيت ديهايدروجينيز (LDH) للمجموعات المدروسة كشفت نتائج هذه الدراسة عن زيادة معنوية (p <0.01) في مستويات c.TnI و CK-MB و AST و LDH بالإضافة إلى انخفاض كبير (p <0.01) في مستوى الأبلين في جميع المرضى الذين يعانون من ß-TM مقارنة لمجموعة التحكم. تم العثور على معامل ارتباط بيرسون (r) أيضًا بين المعلمات البيوكيميائية التي تمت دراستها لمرضى ß-TM بمستوى الحديد، ولوحظ وجود ارتباط معنوي (p <0.01) بين مستوى الفيريتين مع مستويات CK-MB و LDH وAST. بينما لم يكن هناك ارتباط معنوي (P> 0.01) من خلال مستويات apelin و c.TnI. استنتجت الدراسة الحالية وجود مؤشر سريري لتلف أنسجة القلب على المدى القريب ، مما ينذر باستخدام بروتوكولات علاج أكثر كفاءة لإزالة الحديد الزائد من مرضى ß-TM.

تفاصيل المقالة

كيفية الاقتباس
1.
تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق. Baghdad Sci.J [انترنت]. 1 يونيو، 2024 [وثق 3 يونيو، 2025];21(6):2007. موجود في: https://bsj-ojs.uobaghdad.edu.iq/index.php/BSJ/article/view/8352
القسم
article

كيفية الاقتباس

1.
تقييم بعض انزيمات القلب والحديد في مصل مرضى بيتا-ثلاسيميا في مدينة ذي قار ، العراق. Baghdad Sci.J [انترنت]. 1 يونيو، 2024 [وثق 3 يونيو، 2025];21(6):2007. موجود في: https://bsj-ojs.uobaghdad.edu.iq/index.php/BSJ/article/view/8352

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